Naomi Unger, age 27, has recently returned from South America, where she was working as a Peace Corps volunteer. She complains of fatigue, cough, and a high unrelenting temperature for the past 5 days. She is diagnosed with aspergillosis pneumonia and is hospitalized. She is prescribed IV amphotericin B. She uses condoms as her birth control method and has not had sex for 5 months. Her menstrual periods are regular but she reports heavy blood loss. Data obtained from the nursing assessment include the following:  Vital signs: temperature, 103.1°F; pulse, 120; respiration, 28; blood pressure, 100/70  Weight: 110 pounds  CBC: WBC, 18.3; RBC, 3.2; Hgb, 10 g/dL; Hct, 35%  UA: Within normal limits  Chemistry: sodium: 136 mEq/L; potassium: 4.0 mEq/L; chloride: 100 mEq/L; glucose: 100 mg/dL; BUN: 20 mg/dL; creatinine: 1.2 mg/dL; ALT 40; AST 36  ABGs: pH, 7.45; PCO2, 30; HCO3, 29; O2 Sat, 94%  Chest x-ray: infiltrates to left upper and lower lobes  Bronchial washing: positive for aspergillosis The patient is currently on ferrous sulfate, 325 mg PO qd. Prescribed medication includes amphotericin B, intravenous, 250 mg/h over 2 hours. Case Study Questions 1. Provide the rationale for why Ms, Unger is prescribed amphotericin B. (5 pts) 2. What contraindications or precautions would eliminate the use of amphotericin B for Ms. Unger? (5 pts) 3. What other drugs could be considered for the treatment of Ms. Unger's infection? (5 pts) 4. What patient variables are most important to consider for Ms. Unger when assessing her drug therapy? (5 pts) 5. What aspects of core drug knowledge (pharmacotherapeutics, pharmacokinetics, and pharmacodynamics) are especially relevant to consider because they may interact with the patient variables? (5 pts) 6. Which of the findings from the nursing assessment demonstrate the effectiveness of drug therapy with amphotericin B? (5 pts) 7. Which of the findings from the nursing assessment demonstrate possible adverse effects from amphotericin B? (5 pts) 8. What nursing actions are indicated to maximize therapeutic effects? (5 pts) 9. What nursing actions are indicated to minimize adverse effects? (5 pts)