1. What are the different factors that can affect drug disposition? 2. How are therapeutic drugs absorbed, distributed, metabolized, and excreted? What role does cytochrome P 450 play in drug metabolism? 3. What is meant by the term pharmacokinetics? How is drug dosing dependent on a drug's dose-response curve and what factors affect this curve? 4. Which therapeutic parent drugs have active metabolites that must be monitored? Name the metabolites.