Referencing Styles : APA In Part C you will describe mechanism of action of the drug (pharmacodynamics) to achieve a therapeutic result. Outline the mechanism of action of the drug on the body. How does the drug achieve a therapeutic effect? How is the therapeutic effect monitored? What are the optimal value ranges for these measures? Note: Part C: You will write and submit a report addressing the three questions outlined in the task description. This section assesses your ability to define common pathophysiological and pharmacological terms; describe the four pharmacokinetic processes (absorption, distribution, metabolism and elimination); outline key pharmacodynamic principles (eg agonist and antagonists, receptor-drug interactions); outline the major haematological pathologies and malignancies; and demonstrate an understanding of cellular adaptation to injury. Part D. In part D you will link the mechanism of action (your responses in Part C) to the adverse events and contraindications provided for the drug. Make sure you read the supplied synopsis of the role of vitamin K in the body. Q 1. There is a long list of drug interactions given for warfarin. What are the three main reasons for the length of this list? Q 2. A person known to have coeliac disease is noted to be vitamin K deficient. If prescribed warfarin, how would this influence the therapeutic effect of the drug? Q 3. How does liver disease impact the therapeutic effect of warfarin? Would the dose need to be increased or decreased? Q 4. The Full Product Information Sheet (PI) indicates elderly patients who have experienced falls should only be prescribed this drug with caution. What is the rationale for this warning? Q 5. Pregnancy is a contraindication for the prescribing of warfarin. Explain the rationale for this contraindication. Q 6. A person is prescribed an antimicrobial drug from the cephalosporin drug group. This person has been taking warfarin for the last 6 months. Why might this prove problematic? Q 7. A person who is heterozygous for the CYP2C9*2 allele is prescribed warfarin. Outline why knowing this piece of information may be helpful in this person’s care. Q 8. Warfarin is contraindicated in those with severe uncontrolled hypertension. Outline the rationale for this contraindication.